Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo
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چکیده
منابع مشابه
Leukocyte phosphoinositide-3 kinase is required for chemokine-induced, sustained adhesion under flow in vivo
During inflammation, leukocytes roll along the wall of postcapillary venules scanning the surface for immobilized CXCL1, a chemokine that triggers firm adhesion by activating CXCR2 on the neutrophil. PI-3K are signaling molecules important in cellular processes, ranging from cellular differentiation to leukocyte migration. PI-3K can be activated directly by the dimer of heterotrimeric G protein...
متن کاملLeukocyte phosphoinositide-3 kinase {gamma} is required for chemokine-induced, sustained adhesion under flow in vivo.
During inflammation, leukocytes roll along the wall of postcapillary venules scanning the surface for immobilized CXCL1, a chemokine that triggers firm adhesion by activating CXCR2 on the neutrophil. PI-3K are signaling molecules important in cellular processes, ranging from cellular differentiation to leukocyte migration. PI-3Kgamma can be activated directly by the betagamma dimer of heterotri...
متن کاملSpleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis.
BACKGROUND Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. METHODS We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, ...
متن کاملAn Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis
From the Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston (M.E.W.); Division of Rheumatology, University of California at San Diego, San Diego (A.K.); Division of Rheumatology, Stanford University, Palo Alto, CA (M.G.); and Rigel, South San Francisco, CA (T.K.M., E.B.G., D.B.M.). Address reprint requests to Dr. Weinblatt at the D...
متن کاملSpleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth.
Curcumin (diferuloylmethane), a component of dietary spice turmeric (Curcuma longa), has been shown in recent studies to have therapeutic potential in the treatment of cancer, diabetes, arthritis, and osteoporosis. We investigated the ability of curcumin to modulate the growth of B lymphomas. Curcumin inhibited the growth of both murine and human B lymphoma in vitro and murine B lymphoma in viv...
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ژورنال
عنوان ژورنال: BMC Immunology
سال: 2007
ISSN: 1471-2172
DOI: 10.1186/1471-2172-8-31